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Altintas Dogan et al 75 experiment found that liraglutide significantly reduced body weight, decreased inflammatory markers such as IL-6 and MCP-1, increased exertional spirometry (FVC) and carbon monoxide diffusion capacity, and improved COPD assessment test scores, but no significant improvement in FEV1, FEV1/FVC, or 6-minute walk tests, suggesting the possibility that GLP-1RA may reduce inflammatory responses, improve lung function, and mitigate the degree of impaired health in patients with COPD

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A safety review in the Journal of Obesity & Food Metabolism describes six randomized, double-blind, placebo-controlled trials evaluating AOD-9604, including oral dosing studies and longer phase II programs